. Open 24 hours, 7 days a week! What's happening this April. Saturdays. The Route 66 Casino Hotel is now open. Daily Hours of Operation: 7 AM – 2 AM Details on open amenities and frequently asked questions can be. Poker alley and bingo parlor. Route 66 Casino Hotel is a full-service casino, restaurant and hotel property located 17 miles west of downtown Albuquerque on Interstate 40 at Exit route 66 casino hours. Open daily from 7 AM - 2 AM! Under the initial reopening, you can Get Your Kicks on our slot machines and sports betting at The Book. Sundays. Located less than 20 minutes from Downtown Albuquerque, you won't have to worry about traffic lights or. Get your kicks at route 66! Stay and Go Play! Route 66 Casino Hotel. More than 1, slots, craps, roulette and blackjack. Thursdays. The Route 66 Casino Hotel offers over 1, slot and video poker machines, 26 table games, a seat bingo hall, a dedicated poker room with 10 tables, five. Enjoy our indoor pool that features an outdoor sundeck. International buffet, travel center, nightclub, 3-star hotel. Located less than 20 minutes from Downtown Albuquerque, you won't have to worry about traffic lights or commuters, the drive is straight and stress free highway.